プログラム

Sep. 27 (Fri.)13:30-14:30

Poster Discussion

P-1

Hepatic cyst formation and abnormal bile duct development in liver-specific Hhex knockout mice

Tomoya Ueno1, Taichi Yamamoto2, Tamio Noguchi2, Toru Koike1, Nobuyoshi Shiojiri1 (1Department of Biology, Faculty of Science, Shizuoka University, 2Department of Pharmacy, Faculty of Pharmacy, Osaka Ohtani University)

P-2

Reconstruction of Liver Tissues Model Composed of Murine Hepatic Progenitor Cells and Fibroblasts in Dense Collagen Fibrils

Miho TAMAI1, Hiroshi SAKAI2, Shinichi Miyagawa2, Eijiro ADACHI3, Yoh-ichi TAGAWA1 (1Grad. Sch. of Biosci. and Biotech., Tokyo Inst. of Tech., 2Grad. Sch. of Med., Shinshu Univ., 3Grad. Sch. of Med. Sci., Kitasato Univ.)

P-3

Generation of liver progenitors from human iPS cells

Taketomo Kido1, Minoru Tanaka2, Yasuyuki Sakai3, Atsushi Miyajima1 (1Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo , 2Laboratory of Stem Cell Regulation, Institute of Molecular and Cellular Biosciences, The University of Tokyo , 3Institute of Industrial Science, The University of Tokyo)

P-4

Functions of Wnt5a signaling in differentiation of murine hepatic stem/progenitor cells

Sei Kakinuma1,2, Kei Kiyohashi2, Akihide Kamiya3, Yasuhiro Asahina1,2, Hiromitsu Nakauchi4, Mamoru Watanabe2 (1Department of Liver Disease Control, Tokyo Medical and Dental University, 2Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 3Institute of Innovative Science and Technology, Tokai University, 4Division of Stem Cell Therapy, Institute of Medical Science, The University of Tokyo)

P-5

Identification of human induced pluripotent stem cells with hepatic differentiation propensity

Noriko Itaba1, Natsumi Aramaki1, Toshihiro Yasui1, Yoshiaki Matsumi1, Peninah M. Wairagu2, Ai N.H. Phan2, Yansgik Jeong2, Makoto Otsu3, Takahiro Kunisada4, Yukio Nakamura5, Hideyuki Okano6, Goshi Shiota1 (1Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, 2Department of Biochemistry, Wonju College of Medicine, Yonsei University, 3Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, 4Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Gifu University Graduate School of Medicine, 5Cell Engineering Division, RIKEN BioResource Center, 6Department of Physiology, School of Medicine, Keio University)

P-6

Analysis of hepatic lipid metabolism using iHep cells

Shizuka Miura1, Atsushi Suzuki1,2 (1Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, 2Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency)

P-7

Reconstitution of human in vitro liver model consisting of ES/iPS cell-derived hepatic cells and endothelial networks

Sungho Ahn, Yoh-ichi Tagawa (Graduate School of Bioscience and Bioengineering, Tokyo Institute of Technology)

P-8

Chimeric analysis of EGFP and DsRed2 transgenic mice demonstrates polyclonal maintenance of pancreas and liver

Yuuki Taniguchi, Je-Young Ryu, Yoh-ichi Tagawa (Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology)

P-9

In vitro sinusoid-like networks consisting of hepatocytes, endothelial cells and hepatic stellate cells

Tsutomu Murakami, Miho Tamai, Yoh-ichi Tagawa (Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology)

P-10

The Role of Epiregulin During Liver Regeneration: the Possible Function of Promoting the Emergence and Proliferation of Liver Progenitor Cells

Kyoko Tomita, Hiroaki Haga, Kei Mizuno, Tomohiro Katsumi, Chikako Sato, Kazuo Okumoto, Yuko Nishise, Hisayoshi Watanabe, Takafumi Saito, Yoshiyuki Ueno (Yamagata University Department of Gastroenterology)

P-11

P75NTR-positive mesenchymal cells contribute to erythropoiesis in both fetal and adult liver by expressing erythropoietin

Minoru Tanaka, Marika Motomura, Yoshiko Kamiya, Atsushi Miyajima (IMCB, the Univ. of Tokyo)

P-12

Cellular reaction of the humanized chimeric mouse liver after bile-duct ligation

Ami Yanagi1, chihiro Yamasaki1, Yasumi Yoshizane1, Yuji Ishida1,2, Chise Tateno1,2 (1PhoenixBio, Co., Ltd., 2Liver Research Project Center, Hiroshima University)

P-13

Analysis of intrahepatic bile ducts using a high-resolution 3D imaging system

Yasuo Takashima1, Masuyo Kawabata1, Atsushi Suzuki1,2 (1Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, 2Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency)

P-14

Enhanced Nuclear Transglutaminase 2 Activity by Hepatic Cells Following Incubation with Candida albicans

Ronak Shrestha1,2, Susumu Kajiwara2, Soichi Kojima1 (1Micro-signaling Regulation Technology Unit, Division of Bio-function Dynamics Imaging, RIKEN Center for Life Science Technologies, Wako, Saitama 351-0198, Japan, 2Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8501, Japan)

P-15

IGF-I reduces collagen production through induction of collagen degradation via mTOR dependent signaling pathway

Takako Nishikawa1, Tomoaki Tomiya1, Natsuko Ohtomo1, Yukiko Inoue2, Hitoshi Ikeda3, Hiromichi Shirataki4, Kazuhiko Koike1 (1Department of Gastroenterology, University of Tokyo, Tokyo, Japan, 2Division for Health Service Promotion, University of Tokyo, Tokyo, Japan, 3Department of Clinical Laboratory, University of Tokyo, Tokyo, Japan, 4Molecular and Cell Biology, Dokkyo Medical School, Mibu, Tochigi, Japan)

P-16

Role of hepatic M2-like macrophage in liver fibrosis

Eiko SAIJOU, Michitaka MATSUDA, Yutaka ENOMOTO, Minoru TANAKA, Atsushi MIYAJIMA (Laboratory of Cell Growth and Differentiation Institute of Molecular and Cellular Biosciences The University of Tokyo)

P-17

Canine bone marrow cell xenotransplantation in NOD/Shi-scid IL2Rgnull mice promotes carbon tetrachloride-induced hepatic fibrosis

Takashi Kato, Masaharu Hisasue, Kazuhito Segawa, Sakurako Neo, Ryo Tsuchiya (Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University)

P-18

Construction of hepatocyte and endothelial cell co-culture system in hybrid sponge integrated with a microfluidic device

Yi Shang1, Miho Tamai1, Yoichi Fujiyama2, Yoh-ichi Tagawa1 (1Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 2Device Department, Shimadzu Corporation)

P-19

Extracellular matrices (ECMs) weaken the interferon-alpha (IFN-a) signaling through the modulation of nuclear factor kappa B (NFkB) signaling

Takuya Kuwashiro, Iwata Ozaki, Sachiko Matsuhashi, Yasushi Ide, Taiga Otsuka, Toshihiko Mizuta, Keizo Anzai (Saga University Medical faculty Internal medicine)

P-20

Progressive change from fatty liver to steatohepatitis in high fat diet fed and carbon tetrachloride administered mice

Norihiro Kubota, Shoichi Kado, Yuriko Nagata, Norie Masuoka, Mitsuyoshi Kano, Kouji Miyazaki (Yakult Central Institute)

P-21

Suppression of ethanol-induced liver injury in mouse by a novel tripeptide consisted of non-proteinogenic amino acids

Chonnipa Nilubol1, Miho Tamai1, Hidemitsu Uchisawa2, Yoh-ichi Tagawa1 (1Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan, 2Aomori Prefectural Industrial Technology Research Center, Japan)

P-22

Analysis of pathophysiological mechanism in NAFLD responding to hypoxia

Takatomo Arai, Yuki Kato, Nobuhito Goda (Dept. of Life sci. and Med. Biosci., Sch. of Adv. Sci. and Eng., Waseda Univ. )

P-23

p62/SQSTM1 plays a protective role from oxidative injury of steatotic liver in mouse hepatectomy model.

Sanae Haga1, Takeaki Ozawa2, Naoki Morita3, Yayoi Seki1, Yuma Yamada4, Yukari Yasuzaki4, Kazuo Umezawa5, Michitaka Ozaki1 (1Facul Health Sci, Grad Sch Health Sci, Hokkaido Univ , 2Dept Chem, Sch Sci, Univ of Tokyo, 3Bioproduction Res Insti, AIST, 4Facul Pharma Sci, Hokkaido Univ , 5Sch Med, Aichi Med Univ)

P-24

Over-expression of Bcl-xL mutant (FNK) improves the engraftment efficacy of human iPS cell-derived hepatocytes in the liver of uPA/SCID mice

Yasuhito Nagamoto1,2, Kazuo Takayama1,2,3, Katsuhisa Tashiro4, Chise Tateno5, Fuminori Sakurai1, Masashi Tachibana1, Kenji Kawabata4, Kazuo Ikeda6, Yasuhito Tanaka7, Hiroyuki Mizuguchi1,2,3 (1Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 2Laboratory of Hepatocyte Regulation, National Institute of Biomedical Innovation, 3iPS Cell-based Research Project on Hepatic Toxicity and Metabolism, Graduate School of Pharmaceutical Sciences, Osaka University, 4Laboratory of Stem Cell Regulation, National Institute of Biomedical Innovation, 5PhoenixBio Co. Ltd., 6Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka City University, 7Department of Virology and Liver Unit, Graduate School of Medical Sciences, Nagoya City University)

P-25

Hypertension exacerbates liver injury and hepatic fibrosis induced by a choline-deficient L-amino acid-defined diet in rats

Hirofumi Uto1, Shiho Arima1, Rie Ibusuki1, Ryo Kumamoto1, Shirou Tanoue1, Seiichi Mawatari1, Kohei Oda1, Dai Imanaka1, Akihiko Ohshige1, Kotaro Kumagai1, Tsutomu Tamai1, Akihiro Moriuchi1, Makoto Oketani1, Akio Ido1, Hirohito Tsubouchi2 (1Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, 2Department of HGF Tissue Repair and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences)