September 26 (Thu.)
September 27 (Fri.)
September 26 (Thu.)
Sep. 26 (Thu.)9:00-10:30
Session 1 "Development & Signaling"
Chairpersons: Nobuyoshi Shiojiri (Depｔ. of Biology, Graduate School of Science, Shizuoka Univ.)
Yuji Nishikawa (Div. of Tumor Pathology, Dept. of Pathology, Asahikawa Medical Univ.)
Keynote1
Mechanisms of cell fate determination in developing liver
Frederic Lemaigre (Universite catholique de Louvain)
O-1
Lineage plasticity of cholangiocytes and hepatocytes
Naoki Tanimizu, Toshihiro Mitaka (Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine)
O-2
Cellular origins of increased ductular structures in chronic liver injury
Yuji Nishikawa1, Yasuharu Nagahama2, Masayuki Sone2, Xi Chen1, Yoko Okada1, Masahiro Yamamoto1, Bing Xin1, Katsuhiko Enomoto3 (1Div. of Tumor Pathology, Dept. of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan, 2Fujii Memorial Research Institute, Otsuka Pharmaceutical Co. Ltd, 3Department of Pathology, Akita Red Cross Hospital)
O-3
Impaired hepatocyte maturation through inactivation of the C/EBPα gene induces not only abnormal expression of biliary transcription factors but also liver fibrosis
Nobuyoshi Shiojiri, Toru Koike, Takeshi Oitate, Yusuke Akai (Department of Biology, Graduate School of Science, Shizuoka University)
O-4
Notch signaling promotes proliferation of adult liver progenitor cells and progenitor-dependent liver regeneration
Tohru Itoh, Seitaro Ino, Atsushi Miyajima (Institute of Molecular and Cellular Biosciences, The University of Tokyo)
O-5
fibroblast growth factor 19 was aberrantly expressed in cholestatic hepatocytes, and its signal pathways were inappropriately down-regulated in biliary atresia children.
Yasuhiro Hasegawa1, Hiroki Kondou1, Masanobu Kawai2, Takehisa Ueno3, Yuki Miyahara1, Akiko Konishi1, Kie Nakao1, Makiko Tachibana1, Takeshi Kimura1, Kayo Ikeda1, Kazuhiko Bessho1, Yoko Miyoshi1, Toshimi Michigami2, Keiichi Ozono1 (1Department of Pediatrics, Graduate School of Medicine, Osaka University, 2Department of Bone and Mineral Research, Research Institute, Osaka Medical Center for Maternal and Child Health, 3Department of Pediatric Surgery, Graduate School of Medicine, Osaka University)
Sep. 26 (Thu.)10:30-11:45
Session 2 "iPS"
Chairpersons: Hiroshi Nishina (Dept. of Developmental and Regenerative Biology, Medical Research Institute,Tokyo Medical and Dental Univ.)
Hideki Taniguchi (Dept. of Regenerative Medicine, Graduate School of Medicine, Yokohama City Univ.)
Keynote2
Using Human iPS cells to Study Liver Disease and Development
Stephen Duncan (Medical College of Wisconsin)
O-6
Long-term culture of hepatoblast-like cells derived from human ES/iPS cells
Kazuo Takayama1,2,3, Yasuhito Nagamoto1,3, Katsuhisa Tashiro4, Fuminori Sakurai1, Masashi Tachibana1, Kenji Kawabata4, Hiroyuki Mizuguchi1,2,3,5 (1Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 2iPS Cell-based Research Project on Hepatic Toxicity and Metabolism, Graduate School of Pharmaceutical Sciences, Osaka University, 3Laboratory of Hepatocyte Regulation, National Institute of Biomedical Innovation, 4Laboratory of Stem Cell Regulation, National Institute of Biomedical Innovation, 5The Center for Advanced Medical Engineering and Informatics, Osaka University)
O-7
In vitro generation and expansion of bi-potent hepatic progenitor-like cells from human iPS cells
AYAKA YANAGIDA1, Keiichi Ito1, Hiromi Chikada2, Hiromitsu Nakauchi1, Akihide Kamiya2 (1IMSUT, 2Tokai University)
O-8
Generation of hepatic cells from human induced pluripotent stem cells.
Keisuke Sekine, Takanori Takebe, Ran-Ran Zhang, Yasuharu Ueno, Masahiro Enomura, Hiroyuki Koike, Yun-Wen Zheng, Hideki Taniguchi (Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine)
O-9
A Scalable Microculture For Generating Functional Hepatic Cell Spheroids from Human induced Pluripotent Stem Cells
Maho Takayama1, Takanori Takebe2, Reina Miyazaki1, Masaki Kimura2, Hiroyuki Koike2, Masahiro Enomura2, Keisuke Sekine2, Hideki Taniguchi2 (1Department of Regenerative Medicine, Yokohama City University, 2Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University)
Sep. 26 (Thu.)12:00-12:50
Luncheon Seminar 1 (Co-sponsored: MSD) at Conference Hall
Chairperson: Hidekazu Tsukamoto (Professor of Pathology, Keck School of Medicine, Univ. of Southern California)
LS1
Adiponectin and Chronic Organ Disease
Iichiro Shimomura (Professor & Chairman, Department of Metabolic Medicine (Internal Medicine), Graduate School of Medicine Osaka Univ.)
Sep. 26 (Thu.)12:00-12:50
Luncheon Seminar 2 (Co-sponsored: Otsuka) at Room 1101-1102 In Japanese
Chairperson: Kiwamu Okita (Emeritus professor, Department of Gastroenterology and Hepatology,Yamaguchi University Graduate School of Medicine)
LS2
A Lipidomic Analysis of Nonalcoholic Fatty Liver Disease ~ Efficacy of L-Carnitine for Nonalcoholic Steatohepatitis ~
Hajime Sunakozaka (Kanazawa University Hospital)
Sep. 26 (Thu.)13:00-13:45
Special lecture
Chairperson: Kiwamu Okita (Emeritus professor, Department of Gastroenterology and Hepatology,Yamaguchi University Graduate School of Medicine)
SL
Vascularized and functional human liver from an iPSC-derived organ bud transplant
Hideki Taniguchi, Takanori Takebe (Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine)
Sep. 26 (Thu.)13:45-15:10
Session 3 "Liver progenitor cell"
Chairpersons: Atsushi Miyajima (Institute of Molecular and Cellular Biosciences, Univ. of Tokyo)
Tetsuo Takehara (Dep. of Gastroenterology and Hepatology, Osaka Univ. Graduate School of Medicine)
Keynote3
Clonogenic hepatocyte progenitors from the liver, pancreas and gall bladder
Markus Grompe (Oregon Health & Science University)
O-10
Withdrawn
O-11
Novel visualization method reveals connection of adult liver progenitor cells to biliary trees in various liver injuries
Kota Kaneko, Tohru Itoh, Atsushi Miyajima (Cell Growth and Diff., Inst. of Mol. Cell. Bio., Univ. of Tokyo)
O-12
Mesenchymal progenitor cells in mouse fetal liver regulate differentiation and proliferation of hepatoblasts.
Keiichi Ito1, Ayaka Yanagida1, Hiromitsu Nakauchi1, Akihide Kamiya2 (1Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, 2Institute of Innovative Science and Technology, Tokai University)
O-13
Distinct role of EGFR and Met on adult hepatic progenitor cell differentiation in mice
Mitsuteru Kitade1, Hitoshi Yoshiji 1, Thorgeirsson Snorri2, Hiroshi Fukui1 (1The Third Department of Internal Medicine, Nara Medical University, 2Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health)
O-14
Thy1-positive cells transplantation activates the growth of hepatic progenitor cells in recipient rat livers.
Norihisa Ichinohe , Naoki Tanimizu, Toshihiro Mitaka (Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine)
Sep. 26 (Thu.)15:10-16:35
Session 4 "Liver progenitor cell - Hepatocyte"
Chairpersons: Toshihiro Mitaka (Dept. of Tissue Development and Regeneration,Research Institute for Frontier Medicine, Sapporo Medical Univ. School of Medicine)
Atsushi Suzuki (Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University)
Keynote4
Liver progenitor cells: ex vivo and in vivo approaches for cell therapy
George Yeoh (University of Western Australia)
O-15
Functions and gene expressions of sandwich cultured-primary rat hepatocytes on oxygen-permeable membranes under physiological oxygen concentrations for drug screening
Wenjin Xiao1, Hitoshi Matsui2, Marie Shinohara1, Kikuo Komori1, Tomoharu Osada2, Yasuyuki Sakai1 (1Institute of Industrial Science, The University of Tokyo, 2Mitsubishi Chemical Medience)
O-16
Efficient formation of 3D co-cultured liver cell aggregates with direct oxygenation and evaluation of their metabolic functions
Marie Shinohara1, Taketomo Kido2, Kikuo Komori1, Teruo Fujii1, Atsushi Miyajima2, Yasuyuki Sakai 1 (1Institute of Industrial Science, the University of Tokyo, 2Institute of Molecular and Cellular Biosciences, the University of Tokyo)
O-17
Relationship between spacial configuration and hepatocyte-clock of hepatocytes
Hiroaki Oda, Shingo Okubo (Lab. Nutr. Biochem., Nagoya Univ.)
O-18
MATHEMATICAL MODELING TO SIMULATE CELL MIGRATION IN MULTICELLULAR SPHEROIDS COMPRISING HEPATOCYTE AND ENDOTHELIAL CELLS
Nobuhiko Kojima1, Yuka Ogata2, Shinji Nakaoka3, Yasuyuki Sakai2 (1Graduate School of Nanobioscience, Yokohama City University, 2Institute of Industrial Science (IIS), University of Tokyo, 3Center for Integrative Medical Science Center (IMS-RCAI), Riken Yokohama Institute)
O-19
Withdrawn
Sep. 26 (Thu.)17:00-17:50
Evening Seminar (Co-sponsored: Rohto)
Chairperson: Shuji Terai (Associate professor, Dept. of Gastroenterology and Hepatology, Yamaguchi Univ. Graduate School of Medicine)
ES
The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
Takahiro Ochiya (Division of Molecular and Cellular Medicine, National Cancer Center Research Institute )
Sep. 26 (Thu.)18:30-
Banquet (Room "KATSURA" at RIHGA ROYAL HOTEL)
September 27 (Fri.)
Sep. 27 (Fri.)9:00-10:40
Session 5 "Inflammation, Regeneration & Fibrosis 1"
Chairpersons: Yutaka Sasaki (Dept. of Gastroenterology and Hepatology, Kumamoto Univ.)
Sumiko Nagoshi (Dept. of Gastroenter ology & Hepatology, Saitama Medical Univ.)
Keynote5
Macrophage therapy for liver fibrosis and regeneration
Alison Mackinnon (University of Edinburgh)
O-20
Acetaminophen induces synchronized necrotic death of attaching hepatocytes via gap junction
Chieko Saito1,2, Koei Shinzawa1, Yoshihide Tsujimoto1 (1Osaka University Graduate School of Medicine, Dept. of Medical Genetics, 2JSPS)
O-21
Palmitic acid induces cellular injury in primary mouse hepatocytes through the lipid raft clustering
Akira Uchiyama, kazuyoshi Kon, Tomonori Aoyama, Shunhei Yamashina, Satoko Suzuki, Kenichi Ikejima, Sumio Watanabe (Gastroenterology, Juntendo University School of Medicine)
O-22
The rheostat regulating hepatocyte apoptosis by BH3-only proteins in developing and adult liver.
Hayato Hikita, Yoshinobu Saito, Satoshi Tanaka, Tsukasa Kawaguchi, Satoshi Shimizu, Takahiro Kodama, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara (Osaka University Graduate School of Medicine Dep. Gastroenterology and Hepatology)
O-23
Induction of tumor necrosis factor α expression in hepatocytes and involvement of its natural antisense transcript
Mikio Nishizawa1, Emi Yoshigai1, Yoshito Tanaka2, Masaki Kaibori2, Tominori Kimura3, Tadayoshi Okumura2,4, A-Hon Kwon2 (1Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 2Department of Surgery, Kansai Medical University, 3Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 4Research Organization of Science and Technology, Ritsumeikan University)
O-24
HCV NS3 protease plus TNF-α promotes liver fibrosis via stimulating expression and activation of TGF-β type I receptor
Kotaro Sakata1, Mitsuko Hara1, Chiemi Mishima-Tsumagari2,6, Takaho Terada2,3, Noriyuki Watanabe4, So-ichi Yaguchi5, Takehisa Matsumoto2,6, Mikako Shirouzu2,6, Shigeyuki Yokoyama2,3, Keiji Miyazawa5, Hideki Aizaki4, Tetsuro Suzuki7, Takaji Wakita4, Soichi Kojima1 (1Micro-signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, 2RIKEN Systems and Structural Biology Center, 3RIKEN Structural Biology Laboratory, 4Department of Virology II, National Institute of Infectious Diseases, 5Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 6Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 7Department of Infectious Diseases, Hamamatsu University School of Medicine)
O-25
Gab1 scaffolding adaptor protein protects from liver fibrosis in a mouse model of cholestasis
Yuichi Yoshida, Takashi Kizu, Kunimaro Furuta, Satoshi Ogura, Mayumi Egawa, Norihiro Chatani, Hisao Ezaki, Yoshihiro Kamada, Shinichi Kiso, Tetsuo Takehara (Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine)
Sep. 27 (Fri.)10:40-12:20
Session 6 "Inflammation, Regeneration & Fibrosis 2"
Chairpersons: Yutaka Inagaki (Dept. of Regenerative Medicine, Tokai Univ. School of Medicine)
Soichi Kojima (Micro-signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies)
Keynote6
Can hepatic stellate cells be hepatic stem cells?
Kiyasov Andrey (Kazan Federal University)
O-26
The secretory pathway for collagen in liver fibrosis.
Kota Saito, Shin-ichi Fukushima, Toshiaki Katada (Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo)
O-27
Function of Semaphorin 3E in liver fibrosis and regeneration.
Tomoki Yagai1, Minoru Tanaka2, Atsushi Miyajima1 (1Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cell Biosciences, University of Tokyo, 2Laboratory of Stem Cell Regulation, Institute of Molecular and Cell Biosciences, University of Tokyo )
O-28
Mechanism of liver fibrosis induced by Oncostatin M
Michitaka Matsuda, Minoru Tanaka, Atsushi Miyajima (Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, University of Tokyo)
O-29
Beneficial effects of combined treatment with ursodoxycholic acid (UDCA) and Angiotensin-II type1 receptor blocker (ARB) on liver fibrosis development in the rat model of nonalcoholic steatohepatitis.
TADASHI NAMISAKI, Hitoshi Yoshiji, Ryuichi Noguchi, Kei Moriya, Mitsuteru Kitade, Yosuke Aihara, Akitoshi Douhara, Hideto Kawaratani, Norihisa Nishimura, Hiroshi Fukui (The third department of internal medicine, Nara Medical University, Nara, Japan)
O-30
Basic studies for a less invasive liver regeneration therapy for liver cirrhosis using cultured autologous bone marrow-derived mesenchymal stem cells with stabilization of redox homeostasis
Taro Takami1, Shuji Terai1, Quintanilha Luiz Fernando1, Koichi Fujisawa2, Naoki Yamamoto3, Isao Sakaida1 (1Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 2Center for Reparative Medicine, Yamaguchi University Graduate School of Medicine, 3Yamaguchi University Health Administration Center, Yamaguchi University)
O-31
Identification of a Novel Bone Marrow Cell-derived Factor That Suppresses Fibrogenesis and Accelerates Regeneration of Murine Fibrotic Liver
Hideaki Sumiyoshi1, Hiroshi Fukumitsu1, Reiichi Higashiyama1, Sachie Nakao1, Kaori Minakawa1, Minako Sueoka1, Hiromi Chikada2, Akihide Kamiya2, Kiyoshi Higashi3, Koichi Saito3, Yutaka Inagaki1 (1Department of Regenerative Medicine, Tokai University School of Medicine, 2Institute of Innovative Science and Technology, Tokai University, 3Environmental Health Science Laboratory, Sumitomo Chemical Co. Ltd.)
Sep. 27 (Fri.)12:30-13:20
Luncheon Seminar 3 (Co-sponsored: Bayer) "Exploring Stemness of Hepatocellular carcinoma"
Chairperson: Isao Sakaida (Professor & Chairman, Dept. of Gastroenterology and Hepatology, Yamaguchi Univ. Graduate School of Medicine)
LS3
Exploring Stemness of Hepatocellular carcinoma
Yamashita Taro (Assistant Professor, Dept. of General Medicine, Kanazawa Univ. Hospital)
Sep. 27 (Fri.)13:30-14:30
Poster Discussion
Poster Program
Sep. 27 (Fri.)14:30-16:35
Session 7 "Chimera & Cancer" (Co-sponsored: PhoenixBio)
Chairpersons: Goshi Shiota (Div. of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori Univ.)
Chise Tateno (PhoenixBio, Co., Ltd.)
Keynote7
Liver repopulation with human hepatocytes
Markus Grompe (Oregon Health & Science University)
Keynote8
Modelling the human liver with a chimeric mouse
Norman Kneteman (University of Alberta )
O-32
Primary human hepatocytes isolated from mice with humanized livers as a novel in vitro hepatitis B virus infection model
Yuji Ishida1,2, Chihiro Yamasaki1, Ami Yanagi1, Yasumi Yoshizane1, Kazuaki Chayama2,3, Chise Tateno1,2 (1PhoenixBio Co., Ltd., 2Liver Research Project Center, Hiroshima University, 3Department of Gastroenterology and Metabolism Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University)
O-33
Recent improvement and applications of chimeric mice with humanized livers for drug development
Tateno Chise1,2 (1PhoenixBio, Co., Ltd., 2Liver Research Project Center, Hiroshima University)
O-34
A novel mouse model of oncogene yap-dependent abnormal hepatocyte disappearance
Hiroshi Nishina, Norio Miyamura (Tokyo Medical and Dental University)
O-35
Identification of binding proteins of acyclic retinoid in hepatocellular carcinoma cells
Xian-Yang Qin1, Hideki Tatsukawa2, Naoto Ishibashi3, Hisataka Moriwaki4, Soichi Kojima1 (1Micro-signaling Regulation Technology Unit, Center for Life Science Technologies, RIKEN, Japan, 2Graduate School of Pharmaceutical Sciences, Nagoya University, Japan, 3Pharmaceutical Division, KOWA Company, Japan, 4Department of Gastroenterology, Gifu University, Japan)
O-36
Regulation of Accumulation of Nuclear Transglutaminase 2 and Cell Death in Human Hepatocellular Carcinoma by Acyclic Retinoid
Rajan Shrestha1,2, Hiroyuki Kagechika2, Soichi Kojima1,2 (1Micro-signaling Regulation Technology Unit, Center for Life Science Technologies, RIKEN, Wako, Saitama 351-0198, Japan, 2Graduate School of Medical & Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan)
O-37
The effect of chemical chaperon on progression of steatohepatitis in a mouse model of steatohepatitis-related HCC
Kazuyoshi Kon, Kenichi Ikejima, Maki Morinaga, Akira Uchiyama, Tomonori Aoyama, Shunhei Yamashina, Sumio Watanabe (Department of Gastroenterology, Juntendo University School of Medicine)
Sep. 27 (Fri.)16:35-16:45
Closing and Poster Award Ceremony
